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Evaluation of Sequential Phage-Antibiotic Therapy Reveals Enhanced Biofilm Control with Meropenem and Colistin in Clinical MDR Hypervirulent Klebsiella pneumoniae Strain.

Aug 2026 · Journal of Applied Microbiology · 0 citations
Medicine

TL;DR

Sequential phage-antibiotic treatment was effective against MDR-HvKp biofilms, with pre-phage exposure enhancing antibiotic access through biofilm disruption, and the bacteriostatic nature of tigecycline reduced efficacy by affecting phage replication.

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