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Author

B. Shanmugaraj

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Open access Oct 2026

Immunoinformatics-based design and in silico evaluation of a multi-epitope vaccine candidate against Naegleria fowleri.

Primary amoebic meningoencephalitis (PAM) is caused by Naegleria fowleri, a free-living amoeba. It is a fatal infection with more than 95% mortality rate. Even though several combinations of antimicrobial agents were used to treat the condition, the overall survival remains poor and no effective vaccine is currently av...

Kadhirmathiyan Velumani, S. Umapathi, Ashwini Malla et al. · 0 citations
#protein folding Open access Sep 2026

Fusion Partner and ER-Retention Signal Are Associated with Distinct Host Proteomic and Metabolic Responses During Interleukin-15 Production in Nicotiana benthamiana

The results demonstrate that fusion partner and SP/KD targeting strategy jointly shape the host response to recombinant IL-15 expression and should therefore be evaluated together during construct design for plant molecular farming.

A. Savinova, Pipob Suwanchaikasem, Balamurugan Shanmugaraj et al. · 0 citations
Jul 2026

Conserved epitope-driven in silico design of a multi-epitope vaccine against the tick-borne wetland virus.

These computational results suggest that the construct has the potential to induce effective immunity against WELV, however further experimental validations in future have to be performed in order to confirm its efficacy against the pathogen.

Kadhirmathiyan Velumani, Sarumathi Umapathi, B. Shanmugaraj · 0 citations

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