Author

Benjamin J. Auerbach

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#protein folding Open access Oct 2026

Scalable saturation mutagenesis reveals gene regulatory architecture and rare variant effects

Long-context sequence-to-function models enable nucleotide-resolution prediction of regulatory variant effects, motivating comprehensive mutational interrogation across broad genomic contexts. Yet conventional in silico saturation mutagenesis (ISM) scores mutations one at a time, requiring millions of model evaluations...

Han Yuan, Xing-Fan Huang, Benjamin J. Auerbach et al. · bioRxiv · 0 citations

Open access Sep 2026

Single-cell transcriptomics reveals cell-type-specific circadian rhythms and their disruption by acute misalignment in mouse aorta

The circadian molecular clock is a 24-hour cellular timekeeper that influences many features of cardiovascular function. Disruption of the circadian clock via misalignment with the light-dark cycle is associated with a higher incidence of cardiovascular disease and raises cardiovascular risk factors in humans. Nonethel...

Benjamin J. Auerbach, R. Lordan, S. Tang et al. · bioRxiv · 0 citations