Open access
Aug 2026
Early Treatment with Oral Pirfenidone Improves Bladder Function after Contusive Spinal Cord Injury in Mice
It is shown that bladder inflammation and dysfunction precede fibrosis, with TGFβ serving as a key regulatory hub, and early treatment with pirfenidone limits inflammation and fibrosis, normalizes neural signaling, and improves bladder function after SCI.
Alonso Carlos Agustin Isidro, Murugapoopathy Vasikar, Curran Laura et al.
· bioRxiv · 0 citations