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Early Treatment with Oral Pirfenidone Improves Bladder Function after Contusive Spinal Cord Injury in Mice

Alonso Carlos Agustin Isidro Murugapoopathy Vasikar Curran Laura Rivard Leane Bharti Anamitra Kassouf Wassim Janzen Jan David Samuel R. Indra

Aug 2026 · bioRxiv · 0 citations · 28 references

Biology

TL;DR

It is shown that bladder inflammation and dysfunction precede fibrosis, with TGFβ serving as a key regulatory hub, and early treatment with pirfenidone limits inflammation and fibrosis, normalizes neural signaling, and improves bladder function after SCI.

DOI Semantic Scholar

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