Conformational activation of GSK3β by an environmental toxicant suppresses hedgehog signalling and disrupts ciliary homeostasis
It is shown that endosulfan, a banned organochlorine pesticide linked to congenital and reproductive defects, suppresses hedgehog signalling by driving proteolytic processing of GLI transcription factors into repressor forms, establishing a chemical–biological axis through which an environmental toxicant hijacks core k...