Computer-assisted hapten design enables aptamer and hybrid aptamer-antibody rapid assays for detection of citrinin in red yeast rice.
Citrinin (CTN), a nephrotoxic and hepatotoxic mycotoxin frequently found in red yeast rice, requires rapid and reliable detection. Here, six CTN haptens were rationally designed using computational chemistry, and two optimal structures were selected for generating CTN-specific aptamers via systematic evolution of ligan...