Single-cell and Spatial Omics Reveal Spinal Cord Injury Microenvironmental Heterogeneity Relevant to Neural Interfaces and Spinal Neuromodulation.
OBJECTIVE Spinal cord injury (SCI) interrupts brain-spinal communication and causes persistent motor, sensory, and autonomic deficits. MATERIALS AND METHODS We summarize the current clinical and translational evidence on brain-computer interface (BCI)/epidural electrical stimulation (EES)/brain-spinal interface (BSI)...