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PLIN2-PGAM5-regulated lipid droplet-mitochondria contacts drive microglial neuroinflammation after spinal cord injury via fatty acid metabolic reprogramming.

Daoqiang Huang Hong Li Yiqian Luo Pan Jiang Haojie Zhang Dingzhong Cheng Longyou Xiao Kuileung Tong Jia-Le He Zeng-Bo Lu Xuan-Tao Hu Mao Pang Sen-Yu Yao Li-Min Rong Bin Liu
Jul 2026 · Cell Death and Differentiation · 2 citations · 66 references
Medicine

TL;DR

The findings identify the PLIN2-PGAM5 as a critical metabolic-immune pathway and suggest that targeting organelle-contact-mediated metabolic reprogramming represents a potential therapeutic strategy for CNS injury.

DOI PubMed Semantic Scholar
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