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Author

Bo Cheng

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Aug 2026

Nuclear-targeted GDOWN1 potently suppresses tumors by inducing premature transcription termination and exporting Pol Ⅱ CTD phosphatases to activate RB.

A novel interconnected regulatory cascade triggered by nuclear translocation of GDOWN1 is uncovered: it remodels Pol II phosphorylation landscape and induces global transcriptional repression, which further drives cytoplasmic kinase-phosphatase coordination to activate master cell cycle suppressors and ultimately arres...

Zhanwu Zhu, Jin-Jing Hu, Wen-Yuan Zhu et al. · 0 citations

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