Nuclear-targeted GDOWN1 potently suppresses tumors by inducing premature transcription termination and exporting Pol Ⅱ CTD phosphatases to activate RB.

Zhanwu Zhu Jin-Jing Hu Wen-Yuan Zhu Qian-Qian Du Xue-Ying Dong Yun-Pei Su Shao-Bo Wang Jing-Jing Liu Bo Zhang F. Chen Yong-Hong Li Bo Cheng

Aug 2026 · Cell Death and Differentiation · 0 citations · 65 references

Medicine

TL;DR

A novel interconnected regulatory cascade triggered by nuclear translocation of GDOWN1 is uncovered: it remodels Pol II phosphorylation landscape and induces global transcriptional repression, which further drives cytoplasmic kinase-phosphatase coordination to activate master cell cycle suppressors and ultimately arrest cell cycle progression.

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