Temporal lobe epilepsy (TLE) is associated with altered functional connectivity, yet its effects on connector hubs, regions supporting long-range and inter-network communication, remain poorly understood. We used SParsity-based Analysis of Reliable k-hubness to characterize connector hub reorganization in unilateral TL...
Arielle Dascal, Édouard Delaire, A. Ngo et al.· bioRxiv· 0 citations
This study indicates that macroscale directed functional connectivity can reveal biologically grounded, state-dependent principles of signal flow in the human brain.
Younghyun Oh, Yejin Ann, Jae-Joong Lee et al.· Nature Neuroscience· 1 citation
Youth adversity has been associated with alterations in hippocampal structure; however, it remains unclear whether different forms of adversity relate distinctly to its organization across the anterior-posterior and proximal-distal axes. Here, we investigated the associations of different types of adversity with multip...
A surface-intrinsic formulation of hippocampal unfolding is introduced in which geometry, intrinsic coordinates, and correspondence are defined directly on subject-specific surface manifolds, enabling topology-preserving alignment and more accurate characterization of inter-individual variability in health and disease.
J. DeKraker, D. Bansal, M. Snyder et al.· bioRxiv· 0 citations
Dysconnectivity of the temporal-parietal network emerges as a key contributor to affective symptoms in TLE, and limbic network dysfunction additionally impacts cognition, emphasizing the importance of multidisciplinary care targeting both emotion regulation and stress reduction, alongside cognitive rehabilitation, for...
F. Fadaie, B. Caldairou, Boris C. Bernhardt et al.· Epilepsia· 0 citations
HippoGenes provides a framework for exploring the molecular organization of the hippocampus, opening avenues for multiscale integration in health and disease, and is openly available on https://hippogenes.readthedocs.io.
A. Ngo, Sara Larivière, J. Royer et al.· bioRxiv· 0 citations
These findings provide robust evidence that multiscale MRI profiling can identify FCD signatures and contribute to in-vivo subtyping and the novel use of myeloarchitecture profiling and contextualization with macro-scale brain gradients provides new avenues to understand intracortical alterations and the embedding of F...
E. Sahlas, Judy Chen, Arielle Dascal et al.· bioRxiv· 0 citations
Multi-site findings demonstrate marked thalamic circuit fragmentation in TLE, and robustly showed subdivision-specific effects, which point to both mesiotemporal co-lateralization as well as broader system-level involvement.
Rui Ding, K. Xie, Judy Chen et al.· bioRxiv· 0 citations
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