C. Andreescu

Association between plasma brain-derived p-tau variants and anxiety phenotypes in older adults

Evaluating Clustering and Imputation Approaches for Multivariate Longitudinal Clinical Data Using a Real-World eCDF-Copula Resampling Framework

The rapid growth of technologies such as wearable devices and high-throughput sequencing has generated unprecedented volumes of longitudinal data, often with multiple correlated features. This trend highlights the need for robust clustering methods tailored to multi-feature longitudinal datasets. Although previous revi...

Multivariate neural signatures of worry become more differentiated across adolescence and young adulthood: An ultra-high field (7T) fMRI study

Worry is an important contributor to anxiety and depressive disorders, particularly in adolescence. Underlying changes in brain networks are thought to drive development of pathological worry, yet the degree to which neural correlates of worry vary by age is unknown. Here, we use multivariate pattern analysis (MVPA) to...

Proteomic markers linking anxiety phenotypes to Alzheimers disease risk: a multi-analyte proteomic analysis

Distinct anxiety phenotypes map onto dissociable plasma proteomic profiling, converging on a shared neurodegeneration axis reflecting neuronal injury, while diverging across neuroimmune, vascular, and proteostatic domains.

Altered T1w/T2w-FLAIR Ratio in White Matter Hyperintensities as an Indicator of Structural Integrity Loss: Association with Alzheimer’s Disease and Vascular Dementia

Residualized WMH T1w/T2w-FLAIR ratio captures lesion-specific microstructural variation missed by volumetric measures, consistent with vascular-gliotic injury in VD and coexisting amyloid-linked demyelination in AD.