Proteomic markers linking anxiety phenotypes to Alzheimers disease risk: a multi-analyte proteomic analysis

Association between plasma brain-derived p-tau variants and anxiety phenotypes in older adults

Associations of proteomic and epigenetic aging clocks with Alzheimer's disease phenotypes: An exploratory analysis

The potential of plasma proteomic clocks in detecting AD‐related phenotypes and co‐morbidities possibly constitute confounding factors, compromising the performance of proteomic aging models is illustrated.

Health-related factors and their impact on blood-based biomarkers of Alzheimer's disease

In CSF-confirmed participants, age emerged as the most consistent predictor of plasma biomarker levels, particularly NFL and pTau181, which suggests that plasma biomarkers are influenced primarily by age and genetic background rather than by metabolic factors in this cohort.

Proteomic Features and Association Analysis of Late-Onset Depression Based on Behavioral Factorial Analysis and Proteomics

Late-onset depression (LOD) is a common subtype of depression in the elderly, characterized by high disability and recurrence rates, along with poorly understood biological correlates, posing a serious threat to the health of the aging population; moreover, the molecular correlates and diagnostic targets for LOD rema...

Alzheimers disease blood biomarkers reveal proteomic modules of disease progression

Routine and accessible plasma measures can be leveraged to recover reproducible, biologically distinct progression modules that improve characterization of heterogeneous AD and have practical value for risk stratification, trial enrichment, or treatment monitoring.

Insomnia symptoms and stress exposure interact in relation to Alzheimer’s disease biomarkers

It is suggested that chronic stress and sleep disturbances exhibit an interactive relationship in their associations with AD pathology, and the need for further research into interactive effects of multiple modifiable risk factors in the development of AD is highlighted.