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Author

C. Aytekin

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3 papers indexed here

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Review Oct 2026

Immune Checkpoint Dysfunction Remodels Adaptive Immune Receptor Repertoires in CTLA-4 Insufficiency and LRBA Deficiency

It is demonstrated that inherited disruption of the CTLA-4/LRBA axis profoundly remodels AIRRs, preferentially affecting CD8⁺ T-cell diversity while also constraining humoral immunity, and highlight a central role for this immune checkpoint pathway in maintaining adaptive immune repertoire diversity and clonal homeosta...

Gökhan Cildir, Selin Cildir, Rahmi Kutay Erdogan et al. · 0 citations
Case report Open access Sep 2026

Mild Phenotype in Functionally Validated STAT1 Gain‐of‐Function Disease Due to a Novel DNA‐Binding Variant

Signal transducer and activator of transcription 1 (STAT1) gain‐of‐function (GOF) disease is associated with chronic mucocutaneous candidiasis, infections, autoimmunity, and immune dysregulation; however, mutation‐level determinants of phenotypic variability remain incompletely defined. We aimed to describe the clinica...

B. C. Duran, C. Aytekin, M. Tsumura et al. · 0 citations

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