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Author

C. Boeckx

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Open access Oct 2026

Contextualizing the polygenic basis of human brain shape

As the most recently evolved neuroanatomical trait of our species, our globular head shape (‘globularity’) constitutes a promising point of entry to probe possible associations between brain morphology and cognitive traits that may be distinctive of Homo sapiens. To shed additional light on the underlying biology of gl...

Judit Casas-Riu, C. Boeckx · 0 citations
#gene editing Open access Sep 2026

Human-Specific Regulation of CHD2 Controls the Tempo of Cortical Development through Lysosomal Homeostasis

It is demonstrated that CHD2 dosage bidirectionally regulates lysosomal function and autophagosome flux to set the tempo of neuronal maturation, and that CHD2 and lysosomal homeostasis constitute a critical molecular axis regulating the pace of cortical development across evolution and disease.

O. Leonardi, E. Lewerissa, Davide Aprile et al. · 3 citations

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