C. Clish

The Role of Distress-related Metabolic Dysfunction in Ovarian Cancer Development: a pooled case-control study

Background: Evidence suggests chronic distress influences ovarian cancer (OC) etiology and metabolomic profiles. Here, we evaluated the association of a metabolite-based distress score (MDS) and OC risk. Methods: We included two matched case-control studies nested within the Nurses' Health Studies (N=584) and the Prost...

Oxidative balance-related metabolite signature and incident cardiovascular disease and type 2 diabetes within the PREDIMED trial.

Most metabolites showed biologically plausible patterns, correlating with specific pro- and antioxidant exposures and including metabolites previously implicated in oxidative stress-related processes, and inversely associated with CVD and T2D risk at baseline.

Systematic Integration of genomics with transcriptomics for the Study of Coronary Artery Disease and Subclinical Atherosclerosis

Metabolomic profiling reveals distinct and shared biology in COPD and IPF

Alterations in metabolomic profiles of COPD and IPF suggested shared dysregulation of several lipids, however, some metabolites pointed to disease-specific differences.