An integrated cross-omics analysis identifies novel genetic loci and, crucially, uncovers specific nutrient-related metabolic pathways that mediate genetic risk in Aortic aneurysm and its subtypes.
Han-Xi Wang, Junjie Cheng, Jia-Li Yao et al.· Frontiers in Nutrition· 0 citations
Analysis of statistical frameworks for multi-omics integration in AD research focuses on approaches that enable causal inference and gene prioritization, with a focus on approaches that enable causal inference and gene prioritization.
Zhuolan Li· Journal of Clinical Technolo...· 0 citations
Liver fat largely sets the direction of T2D risk, whereas the fate of that lipid, retained in the liver with low circulating ApoB or exported as ApoB-containing lipoproteins, sets the direction of CAD risk.
X. Jiang, N. HirschmuÌller, H. Taylor et al.· medRxiv· 0 citations
This study identified PARP1, SDCCAG8, FST, FOLH1, and NCAN as genetically prioritized candidate proteins for CA, with PARP1 showing the most consistent evidence across analyses.
Da Gao, Hai-Yan Lin, Sheng-Jie Wang et al.· Cardiovascular Therapeutics· 0 citations
Genetic liability to DR is associated with an increased risk of AD and is accompanied by shared expression-mediated effects and convergent neurovascular-metabolic pathways, which support the possibility that DR may serve as a clinically accessible indicator of increased neurodegenerative vulnerability.
Jing Li, Qian Liu, Qian Ma et al.· Journal of Global Health· 0 citations
Findings provide new insights into the genetic and transcriptomic landscape of hypertension in Asians and may guide precision medicine approaches for risk prediction and therapeutic development.
Sheng-Nan Chang, Guan-Wei Lee, J. Chen et al.· Journal of Hypertension· 0 citations
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