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Author

C. Guyeux

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Open access Aug 2026

Rv0810c: a genus-conserved, structurally ordered small protein of unknown function carrying DUF3073 in Mycobacterium tuberculosis

Small annotated open reading frames are the most neglected part of the functionally un-characterised Mycobacterium tuberculosis genome. We revisit Rv0810c, a 60-residue protein carrying the unknown-function domain DUF3073 (Pfam PF11273), flagged as an Actinobacteria-signature protein in 2006 but never studied since. Rv...

C. Guyeux · 0 citations
#protein folding Open access Sep 2026

A conserved cysteine–histidine–glutamate metal site identifies DUF501 (Rv1025), an essential uncharacterised protein family of Mycobacterium tuberculosis, as a candidate metalloenzyme and drug target

It is proposed that DUF501 is a metal-binding protein and candidate metalloenzyme, the first functional hypothesis for this family, whose conserved, essential metal pocket is a promising drug target.

C. Guyeux · 0 citations

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