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Author

C. Heinis

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Open access Sep 2026

Chemical Synthesis and Functional Screening of an 800 000-Member Library Using a Peptide-Pairing Strategy.

Peptide library generation by chemical synthesis allows using a wide range of non-canonical amino acids and thus the screening of chemically and structurally highly diverse libraries. However, despite recent improvements in high-throughput synthesis such as solid-phase peptide synthesis in 384-well plates, the size of...

Anne Zarda, Xing-Wang Deng, Edward J. Will et al. · 0 citations
Jul 2026

Peptide ligand discovery of G protein-coupled receptors

This Primer outlines experimental and computational workflows tailored to peptide–GPCR interactions, including in silico peptide mining, deorphanization strategies, library-based screening platforms, modern pathway-resolved biosensor assays, and approaches for peptide stabilization and optimization strategies to addres...

J. Hermes, Marin Matic, H. Yeung et al. · 0 citations

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