Abstract Background Bipolar disorders (BD) are associated with a wide range of brain white matter abnormalities, but results vary across studies. This heterogeneity likely relates to effects of additional clinical/diagnostic variables, including medications and obesity, on white matter in BD. In this mega-analysis, we...
Lorielle M. F. Dietze, Sean R. McWhinney, P. Favre et al.· Psychological Medicine· 0 citations
BACKGROUND
The accurate detection of clinical symptoms in electronic health records (EHRs) is pivotal for advancing large-scale genetic and longitudinal studies in psychiatry. Free-text clinical notes are an essential source of symptom-level information, particularly in psychiatry; however, the automated extraction of...
C. Frydman-Gani, A. Arias, M. Perez Vallejo et al.· Journal of Medical Internet...· 0 citations
In this study, we present the largest rare coding variant association study of schizophrenia to date, with 87,959 schizophrenia cases and 150,587 controls. We identify 16 genes at exome-wide significance: SETD1A, ZMYM2, HERC1, RB1CC1, SCAF1, XPO7, SP4, FYN, PPP3CA, CUL1, HDAC9, JARID2, ATP9A, PTK2, STAG1, and SCN2A, an...
J. Sealock, C. Dowd, Calwing Liao et al.· bioRxiv· 1 citation
Together, these results implicate a constellation of rare variants that map onto neuronal biology and demonstrate that diverse global populations converge on shared genetic signals underlying BD risk.
Calwing Liao, Robert Ye, J. Sealock et al.· medRxiv· 0 citations
Genetic studies of serious mental illness (SMI, including schizophrenia and bipolar disorder) have implicated two classes of risk variant: common variants1-3, each of small effect but collectively accounting for most population-level risk, and ultra-rare coding variants4,5 which confer large risk in a small number of i...
Greta Gerdes, V. Tozzo, S. Service et al.· medRxiv· 0 citations
General-purpose pre-trained encoders had strong performance for psychiatric concept extraction from Spanish EHRs, and the utility of these relatively lightweight models for scalable, accurate and reproducible detection of psychiatric concepts in Spanish-language EHRs is highlighted.
X. Xue, C. Frydman-Gani, A. Arias et al.· medRxiv· 1 citation
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