Investigating protein conformational ensembles by native mass spectrometry and complementary biophysical techniques—the case of α-synuclein
One of the challenges of modern structural biology is to account for protein structural dynamics. Intrinsically disordered proteins (IDPs), which do not fold spontaneously into a defined conformation, existing, instead, as highly heterogeneous conformational ensembles, provide an extreme and challenging example of prot...
S. Brocca, E. Ponzini, C. Santambrogio et al.
· Frontiers in Biophysics · 0 citations