AIM
The aim of this study was to evaluate the risk factors for CMV reactivation and the effects of CMV on HSCT outcomes in patients managed using a standard prophylaxis and preemptive treatment approach in settings where letermovir prophylaxis could not be used.
METHODS
Patients who underwent HSCT between January 200...
It is demonstrated that inherited disruption of the CTLA-4/LRBA axis profoundly remodels AIRRs, preferentially affecting CD8⁺ T-cell diversity while also constraining humoral immunity, and highlight a central role for this immune checkpoint pathway in maintaining adaptive immune repertoire diversity and clonal homeosta...
Gökhan Cildir, Selin Cildir, Rahmi Kutay Erdogan et al.· Clinical reviews in allergy...· 0 citations
The Nuclear Factor Kappa B (NF-kB) signalling pathway is essential for regulating inflammation, cell survival, and adaptive immune responses through its canonical (NF-κB1-associated) and noncanonical (NF-κB2-associated) branches. The canonical pathway mediates rapid and broad reactions to immune stimuli, whereas the no...
Selin Sevinç, Candan Islamoğlu, Şule Haskoloğlu et al.· Scandinavian Journal of Immu...· 0 citations
Early immunologic evaluation and timely, individualized consideration of HSCT may support optimized management in children and adolescents, in whom cancer may be the first manifestation of IEI.
Nazli Deveci Demirbas, Z. Haskoloğlu, Tutku Baylan et al.· Frontiers in Immunology· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
