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Caroline M. Li

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#protein folding Open access Sep 2026

Second-Generation AOH1996 Analogues with Enhanced Pharmacological Properties for Targeting PCNA

Proliferating Cell Nuclear Antigen (PCNA) plays a critical role in at least 11 distinct cellular pathways. Tumor cells express an acidic isoform of the protein (caPCNA), while nonmalignant cells express only a basic isoform (nmPCNA). We previously identified AOH1996 as a first-in-class, orally bioavailable small mole...

Pouya Haratipour, Maryam Zangi, Long Gu et al. · 0 citations

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