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Author

Cayetana Arnaiz

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Open access Sep 2026

Tau isoforms modulate the axon initial segment controlling axonal trafficking and neuronal excitability

The axon initial segment (AIS) is a specialized neuronal compartment integrating action potential initiation with selective control of axonal trafficking. The microtubule-associated protein tau is a central regulator of cytoskeletal organization and transport, yet how distinct tau isoforms contribute to AIS development...

Cayetana Arnaiz, Gonzalo Escalante, Lautaro Rodriguez Donghi et al. · 0 citations
Jul 2026

Huntingtin is a cell-autonomous regulator of neuropeptide trafficking and clock output

Through targeted genetic knock-down, huntingtin is identified as a cell-autonomous regulator of neuropeptide trafficking, neuronal excitability and circadian output and carries direct relevance for HD therapeutic strategies, particularly those involving huntingtin-lowering approaches.

Agustina Bruno-Vignolo, Cayetana Arnaiz, Florencia Fernández-Chiappe et al. · 0 citations

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