Huntingtin is a cell-autonomous regulator of neuropeptide trafficking and clock output

Agustina Bruno-Vignolo Cayetana Arnaiz Florencia Fernández-Chiappe Ana Ricciuti L. A. Duarte Ivana Ducrey I. Linenberg C. Pollak P. Ballestero Marina Propato-Lots Camila Sofía Falzone E. J. Beckwith T. Falzone N. Muraro

Jul 2026 · bioRxiv · 0 citations

Biology

TL;DR

Through targeted genetic knock-down, huntingtin is identified as a cell-autonomous regulator of neuropeptide trafficking, neuronal excitability and circadian output and carries direct relevance for HD therapeutic strategies, particularly those involving huntingtin-lowering approaches.

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