Author

Chamali Thalagaha Mudiyanselage

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Open access Sep 2026

RNA-Binding Peptide Influences Epitranscriptomic Regulation by Preferentially Binding to Unmodified RNAs Targeted by NSUN2

5-Methylcytosine (m5C) is a widespread mRNA modification that regulates gene expression and is frequently dysregulated in cancer. Here, we used phage display to identify peptides that bind an NSUN2 consensus RNA sequence in either its unmodified (UN2-RNA) or m5C-modified (MN2-RNA) form. A single peptide, un2p1 (TDYSTHR...

Chathurani Ekanayake, Aftab Mollah, Maelee Thompson et al. · Biomolecules · 0 citations

#protein folding Open access Sep 2026

N6-Methyladenosine RNA Modifications Influence the Stability of FUS-Dependent Biological Condensate Formation

Findings indicate that while protein–protein interactions may initiate LLPS, m6A-modulated RNA–protein interactions govern condensate growth and stability, and provide a mechanistic insight into how epitranscriptomic modifications regulate biomolecular condensation and influence cellular organization, gene regulation,...

Chamali Thalagaha Mudiyanselage, Milan Pandey, Sudeshi M. Abedeera et al. · ACS Bio & Med Chem Au · 0 citations