Metabolic engineering of Klebsiella oxytoca for highly selective meso-2,3-butanediol production with minimized byproducts.
Producing enantiopure meso-2,3-butanediol (meso-2,3-BDO) with minimal organic acid byproducts is critical for its commercial applications in specialized polymers and cosmetics. In this study, we developed a highly selective and robust Klebsiella oxytoca platform using stepwise metabolic engineering and bioprocess optim...