Findings support nilotinib as a promising therapeutic candidate for KRAS-mutant NSCLC after a structure-based drug repurposing approach was employed to screen FDA-approved compounds targeting key regulators to the MAPK signalling pathway.
Anisha Jain, Chandan Dharmashekar, B. S et al.· Scientific Reports· 0 citations
HFD feeding caused insulin resistance and impaired iBAT mitochondrial functions and thermogenic activity, due to lipid accumulation, and chronic cold exposure improved insulin sensitivity and restored iBAT oxidative metabolism and mitochondrial functions.
A. Rengaraj, G. T. Le, Chandan Dharmashekar et al.· MAGMA· 0 citations
These findings provide a preliminary mechanistic and experimental framework for DCA as a dietary FTO inhibitor in breast cancer, necessitating further validation through orthogonal target engagement assays, m6A quantification, and in vivo tumor models.
Shuaib Pasha, S. Harishkumar, Revanth Handralu Chandraiah et al.· Naunyn-Schmiedeberg's Archiv...· 0 citations
The crude ethanolic extract of O. tenuiflorum demonstrated consistent, multi-target bioactivity, combining antioxidant, anti-inflammatory, and cytotoxic effects, supporting its potential as a chemopreventive and therapeutic agent against CRC.
Aishwarya H. K., S. Harishkumar, Pruthvi Gowda et al.· Frontiers in Oncology· 0 citations
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