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Open access Aug 2026

Finerenone Alleviates Cardiac Microvascular Injury and Neutrophil Extracellular Traps Formation in Diabetic Cardiomyopathy via Regulating AKT1 Phosphorylation

Diabetes mellitus is commonly featured with cardiac microvascular dysfunction and chronic low‐grade inflammation, contributing to the progression of diabetic cardiomyopathy (DCM). Finerenone confers cardio‐renal protection in diabetic settings, yet its underlying mechanisms remain incompletely defined.

Su Li, He-Xi Zhang, Muyin Liu et al. · 0 citations
Open access Oct 2026

LGR6 couples maresin 1 signaling to glycolytic flux and protein lactylation for the rescue of diabetic cardiomyopathy

ABSTRACT Background Diabetic cardiomyopathy (DbCM) is driven by metabolic inflexibility and impaired mitochondrial clearance. While the pro‐resolving lipid mediator Maresin 1 (MaR1) shows therapeutic promise, its capacity to correct the underlying metabolic‐epigenetic disturbances in DbCM remains undefined. Materials D...

Bin Feng, Chao Chen, Lin Chen et al. · 0 citations

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