Open access
Finerenone Alleviates Cardiac Microvascular Injury and Neutrophil Extracellular Traps Formation in Diabetic Cardiomyopathy via Regulating AKT1 Phosphorylation
Su Li
He-Xi Zhang
Muyin Liu
Wen-Tao Zhu
Xiao-Pei Yan
Wenyan Qiu
Yuan Tian
Xiao-Yu Lian
Dan-Bo Lu
Zhang-Wei Chen
Chao Chen
Yu-Qiong Chen
Ju-Ying Qian
Medicine
Abstract
Diabetes mellitus is commonly featured with cardiac microvascular dysfunction and chronic low‐grade inflammation, contributing to the progression of diabetic cardiomyopathy (DCM). Finerenone confers cardio‐renal protection in diabetic settings, yet its underlying mechanisms remain incompletely defined.