Author

Chao Song

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Open access Sep 2026

Environmental PFOA exposure and the risk of metabolic dysfunction-associated steatotic liver disease: An integrated computational toxicology and multi-omics study

Background Perfluorooctanoic acid (PFOA), a pervasive environmental pollutant, has been implicated in hepatic injury and metabolic dysfunction. However, its role as an environmental risk factor in the pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) remains incompletely understood, parti...

Tianyu Zhang, Yu Yuan, Chun-Li Lin et al. · PLoS ONE · 0 citations

Jul 2026

Integrated bioinformatics and experimental validation reveal that kaempferol ameliorates intervertebral disc degeneration via dual anti-inflammatory and anti-aging pathways.

This study systematically analyzed the molecular mechanism by which kaempferol improves IVDD through multi-target regulation by integrating bioinformatics analysis, animal experiments, and cell models, and reveals for the first time that kaempferol upregulates core gene networks such as AURKB and CCNB1 while suppressin...

Dong-Yang Li, Xiao-Fei Wu, Feng Chen et al. · Naunyn-Schmiedeberg's Archiv... · 0 citations

Jul 2026

ZBP1-driven PANoptosis in granulosa cells mediates follicular arrest in PCOS: integrated transcriptomic evidence and baicalin's therapeutic potential.

A novel ZBP1-driven PANoptotic cascade underlying follicular arrest in PCOS is elucidated and baicalin should be viewed as a promising mechanistic lead rather than an established therapeutic agent; rigorous in vivo studies and clinical evaluation are indispensable prerequisites before any translational application can...

Jiahui Ye, Xiaoxiao Zhao, Si-Yuan Cen et al. · Naunyn-Schmiedeberg's Archiv... · 0 citations