ZBP1-driven PANoptosis in granulosa cells mediates follicular arrest in PCOS: integrated transcriptomic evidence and baicalin's therapeutic potential.

Jiahui Ye Xiaoxiao Zhao Si-Yuan Cen Bixia Zhang Hengzhen He Chao Song Pinglan Ma Han-Mei Lin

Jul 2026 · Naunyn-Schmiedeberg's Archives of Pharmacology · 0 citations · 48 references

Medicine

TL;DR

A novel ZBP1-driven PANoptotic cascade underlying follicular arrest in PCOS is elucidated and baicalin should be viewed as a promising mechanistic lead rather than an established therapeutic agent; rigorous in vivo studies and clinical evaluation are indispensable prerequisites before any translational application can be considered.

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