Author

Chaoyue Ouyang

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Open access Sep 2026

Aberrant phase separation from a rare ABI3 mutation drives microglial dysfunction and Alzheimer's risk

Although the ABI3 S209F variant is a recognized genetic risk for Alzheimer's disease (AD), its pathogenic mechanism remains elusive.

Sheng-Nan Li, Jiong-Tong Lu, Kai-Xing Zeng et al. · Alzheimer's & Dementia · 0 citations

Open access Jul 2026

Metabolic reprogramming via SIRT2-deficient microglial large extracellular vesicles ameliorates alzheimer's pathology.

LEVs are identified as a critical vesicle subtype mediating the effects of SIRT2 knockdown and support a cell-free therapeutic strategy for AD centered on EVs-driven metabolic reprogramming of microglia.

Xiaolu Tang, Rui Chen, Jiawei Xing et al. · Journal of Neuroinflammation · 0 citations