Open access
Aberrant phase separation from a rare ABI3 mutation drives microglial dysfunction and Alzheimer's risk
Sheng-Nan Li
Jiong-Tong Lu
Kai-Xing Zeng
Xing-Yu Lu
Jia-Hao Zhang
Si-Fan Feng
Chun-Mei Liang
Yu-Jie Cai
Shi Yao
Qing Huang
Guo-Cong Liang
Rui Chen
Li Li
Fu-Bin Ma
Jia-Wei Xing
Chao-Yue Ouyang
Lv Luo
Jia-Ying Wang
You Li
Sheng-Bo He
Yuan-Yuan Zhao
Yan Wang
Li-Li Cui
Medicine
Abstract
Although the ABI3 S209F variant is a recognized genetic risk for Alzheimer's disease (AD), its pathogenic mechanism remains elusive.