Author

Charles S. Decarli

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Open access Sep 2026

Cardiovascular risk factors and regional neuropathology in autopsy-confirmed Alzheimer disease.

Cardiovascular risk factors are implicated in Alzheimer disease (AD) progression and its neuropathological hallmarks but their specific contributions to regional brain pathology within AD remain understudied. In this cohort study (n = 276), we examined associations between diabetes, hypertension, and hypercholesterolem...

David Garcia, Hsin-Pei Wang, Naomi Saito et al. · Journal of Neuropathology an... · 0 citations

Open access Sep 2026

CSF proteomics and machine learning reveal distinct stages across the Alzheimer’s disease continuum

These findings uncover protein signatures that reflect underlying AD biology and provide a foundation for stage-specific biomarkers and therapeutic targeting, with important implications for patient stratification and personalized intervention strategies.

Saima Rathore, E. Dammer, Anantharaman Shantaraman et al. · Molecular Neurodegeneration · 0 citations

#protein folding Open access Aug 2026

Learning precise segmentation of neurofibrillary tangles from rapid manual point annotations

A scalable, open-source, deep-learning approach to quantify NFT burden in digital whole slide images (WSIs) of post-mortem human brain tissue and openly releases this multi-institution deep-learning pipeline to provide detailed NFT spatial distribution and morphology analysis capability at a scale otherwise infeasible...

S. Ghandian, Liane Albarghouthi, Kiana Nava et al. · Scientific Reports · 0 citations