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Author

Chenbo Ding

3 papers indexed here

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Open access Aug 2026

Blocking the m6Am methyltransferase PCIF1 in macrophages attenuates colitis progression by preventing neuronal damage

It is demonstrated that colonic macrophage-mediated extracellular matrix (ECM) remodeling orchestrates enteric neuronal maturation and dictates colitis progression and the m6Am machinery is illuminated as a promising therapeutic target for preventing neuronal loss in IBD patients.

Chen-Bo Ding, Jia-Cheng Zhao, Tian-Hua Zhao et al. · 0 citations
Open access Jul 2026

Blocking the m6Am methyltransferase PCIF1 releases STAT1-mediated Th1 immunity to potentiate cancer immunotherapy

It is shown, by genomic deletion of PCIF1 specifically in T cells, that PCIF1 represses STAT1 translation via this important mRNA modification, and thereby preventing T cell activation and enforcing a naïve T cell phenotype.

Jian-Song Huang, Jing Zhou, Xiao Liu et al. · 1 citation

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