Blocking the m6Am methyltransferase PCIF1 in macrophages attenuates colitis progression by preventing neuronal damage

Dioscin activates myeloid AMPK to restore Lgr5⁺ stem cell homeostasis and promote mucosal repair in ulcerative colitis.

Dioscin ameliorates experimental colitis and dysplasia by activating myeloid AMPK signaling, inhibiting IL-1β-driven macrophage-ISC dysregulation, and restoring epithelial regeneration, highlighting macrophage metabolic reprogramming as a therapeutic strategy and identifying myeloid AMPK as a potential target for UC in...

MrgprD-mediated macrophage polarization drives chemically induced colitis in mice.

Inflammatory bowel disease (IBD) is characterized by aberrant immune responses in the gut. Mas-related G protein-coupled receptor D (MrgprD), which is primarily expressed in sensory neurons of the dorsal root ganglia (DRG), is known to promote neuroinflammation. However, its potential role in driving intestinal inflamm...

NINJ2 alleviates inflammatory bowel disease by regulating the macrophage ZBP1-PANoptosis pathway

Inflammatory bowel disease (IBD) is a chronic, relapsing intestinal disorder with a complex etiology and incompletely understood pathogenesis, posing significant challenges for clinical management. The NINJ2 gene is located on chromosome 12, a region enriched with IBD susceptibility loci, and is highly expressed...

UCHL1 Promotes M1 Macrophage Polarization and Inflammation in Chronic Rhinosinusitis by Stabilizing HIF-1α.

Findings indicate that UCHL1 drives M1 macrophage polarization and exacerbates CRS inflammation by stabilizing HIF‑1α through deubiquitination, highlighting UCHL1 as a potential therapeutic target in CRS.

Histone lactylation regulates macrophage polarization and metabolic homeostasis during hypoxic lung injury.

The M1-to-M2 macrophage phenotypic switch is critical for resolving inflammation and restoring homeostasis in hypoxic lung injury, but the underlying molecular mechanisms are unclear. Here, we show that hypoxia-induced histone lactylation (Kla) upregulates FTO via HIF1a-P300 interaction; lactylation-driven FTO then pro...

CD300a Blockade attenuates renal fibrosis by enhancing macrophage efferocytosis and neutrophil MMP9 production