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A29, safe, potent multi-mechanistic lead, exerts multimodal anti-Xoo effects by disrupting key processes, virulence, and promising as novel agrochemical for BLB.
Mechanical studies revealed H6 inhibits biofilm and extracellular polysaccharide formation, disrupts membrane integrity, induces ROS accumulation, and promotes lipid peroxidation, underscoring H6 as a promising bactericidal agent, demonstrating considerable potential in sustainable management of plant bacterial disease...
In vivo validation in PC-3 xenograft mice confirmed that 11 M exerted robust tumor growth suppression with low systemic toxicity, accompanied by DNMT3A downregulation and MAPK pathway activation, substantiating its multi-target therapeutic mechanism.
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