Sep 2026
Kappa opioid receptor-dependent depressive-like behaviors associated with morphine withdrawal contribute to stress-induced reinstatement of morphine seeking.
Findings support the idea that negative affective states during opioid withdrawal may drive relapse vulnerability, and the dynorphin/KOR system represents a critical therapeutic target for reducing negative effects and preventing relapse.
An-An Liu, Pan-Wen Liu, Jia-Qin Luo et al.
· Neuropsychopharmacology · 0 citations