Kappa opioid receptor-dependent depressive-like behaviors associated with morphine withdrawal contribute to stress-induced reinstatement of morphine seeking.

Repeated cocaine exposure and prolonged withdrawal drive morphological and molecular remodeling of hippocampal microglia in response to acute stress.

Repeated cocaine exposure during adolescence disrupts physiological brain maturation, inducing persistent neuroplastic adaptations that evolve throughout withdrawal. Because stressful experiences are among the most powerful triggers of relapse during abstinence, uncovering how cocaine withdrawal affects the neurobiolog...

Cocaine disrupts stress resilience through state-dependent dopaminergic mechanisms in the nucleus accumbens.

BACKGROUND Depression and substance use disorders frequently co-occur, yet it remains unclear whether similar depression-related behaviors reflect a common underlying neural state. Cocaine use is associated with worsening depressive symptoms, suggesting that drug exposure may interact with pre-existing behavioral state...

BLA kappa opioid receptor inputs to the BNST mediate social stress-induced increases in alcohol drinking.

Aversive social experiences can increase alcohol consumption and precipitate relapse during abstinence. Individuals who drink to alleviate social stress are at a heightened risk for developing an alcohol use disorder (AUD). In rodents, repeated social defeat stress (SDS) enhances motivation to consume alcohol, yet the...

Cannabidiol prevents fear extinction deficits caused by single prolonged stress in rats: possible involvement of serotoninergic, cannabinoid, and nitric mechanisms.

Post-traumatic stress disorder (PTSD) involves impaired extinction learning, autonomic and neuroendocrine dysregulation, and first-line selective serotonin reuptake inhibitors (SSRIs) show limited efficacy. We investigated effects and mechanisms of cannabidiol (CBD) on fear deficits induced by the single prolonged stre...

Stress-induced reinstatement of nicotine conditioned place preference in a rodent model of dopamine dysregulation: genetic, behavioral and molecular correlates of drug abuse vulnerability.

Negative Affective States Are Not Detected in Rats Following an Intravenous Self‐Administration Regimen Leading to Incubation of Oxycodone Craving

ABSTRACT In rats, cue‐induced opioid craving intensifies (incubates) during abstinence from opioid self‐administration and then remains high for a prolonged period. The prolonged plateau models persistent vulnerability to cue‐induced craving and relapse in humans recovering from opioid use disorder. However, a very sig...