Jul 2026
Precise DNA base editing using AlphaFold3-based contact modelling
Haowei Meng, Zhixin Lei, Yongchang Yan et al.
· Nature · 3 citations
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Open access
Jul 2026
Blocking the m6Am methyltransferase PCIF1 releases STAT1-mediated Th1 immunity to potentiate cancer immunotherapy
Naïve T cells maintain a delicate balance between quiescence and rapid activation, which involves multiple layers of regulation beyond transcription. Here, we identify the RNA modification N6,2’-O-dimethyladenosine (m6Am) and its methyltransferase PCIF1 as critical enforcers of T cell quiescence. During CD4+ T cell act...
Jiansong Huang, Jing Zhou, Xiao Liu et al.
· Nature Communications · 1 citation