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Author

Christian Lachner

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Open access Oct 2026

Combining Raw Score and Normative Score Cut-Offs for Remote Digital Cognitive Screening: Impact on Sensitivity and Specificity in Cognitively Unimpaired Participants and Participants With Mild Cognitive Impairment and Dementia

Objective: The Mayo Test Drive (MTD) screening battery is a digital, self-administered, web-based cognitive assessment (Stricker et al., 2025 TCN). We aimed to compare diagnostic accuracy of raw versus normative score approaches to distinguishing cognitively unimpaired (CU) from mild cognitive impairment/mild dementi...

Morgan A. Hughes, Alyssa N. Kaser, Elizabeth A. Boots et al. · 0 citations
Open access Oct 2026

Clinical Factors Associated With Discordant Plasma P-Tau217 and Established Alzheimer Disease Biomarkers.

BACKGROUND AND OBJECTIVES Plasma phosphorylated tau (p-tau) 217 is increasingly used for Alzheimer disease (AD) diagnosis and treatment decisions but may be discordant with established AD biomarkers. False-positive (FP) plasma results may lead to overtreatment and false-negative (FN) results to missed or delayed diseas...

D. Shir, A. Algeciras-Schimnich, Y. Piura et al. · 0 citations
Open access Sep 2026

Diagnostic accuracy of remote self-administered digital cognitive assessment by clinical diagnosis and Alzheimer’s disease PET imaging biomarkers

INTRODUCTIONCognitive characterization is increasingly important for Alzheimers disease treatment decisions, highlighting the need for scalable cognitive assessment. We evaluated the diagnostic accuracy of a remote self-administered cognitive screening battery, Mayo Test Drive (MTD), across clinically and biologically...

N. Stricker, Elizabeth A. Boots, Rita L. Taylor et al. · 0 citations
Open access Aug 2026

Optimized plasma p‐tau217 and p‐tau217/Aβ42 cutoffs enhance detection of pre‐clinical Alzheimer's disease across diverse participants

Plasma p‐tau217 and p‐tau217/Aβ42 reliably identify non‐Hispanic White individuals with symptomatic and pre‐clinical AD. However, performance across ethnoracially diverse groups remains unknown.

Y. Piura, P. Aduen, Leah Schecter et al. · 0 citations
Open access Jul 2026

Targeted proteomics of postmortem human brain reveals neurobiologic heterogeneity in Alzheimer’s disease using NULISA technology

Proteomic differences in synapse integrity, tau post-translational modification, and ubiquitination associated with age at symptomatic onset and corticolimbic distribution of tangle pathology are observed.

S. R. Dunlop, Sarah J. Lincoln, Zhongwei Peng et al. · 0 citations

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