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Targeted proteomics of postmortem human brain reveals neurobiologic heterogeneity in Alzheimer’s disease using NULISA technology

S. R. Dunlop Sarah J. Lincoln Zhongwei Peng N. Graff-Radford Christian Lachner Gregory S. Day Jessica F. Tranovich R. Reichard Dennis W. Dickson Ronald Petersen Bradley F. Boeve Aivi T. Nguyen L. Grinberg J. Graff-Radford A. Algeciras-Schimnich Melissa E. Murray
Jul 2026 · bioRxiv · 0 citations · 32 references
Biology Medicine

TL;DR

Proteomic differences in synapse integrity, tau post-translational modification, and ubiquitination associated with age at symptomatic onset and corticolimbic distribution of tangle pathology are observed.

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