Characterizing temporal dynamics during aging is crucial to understanding the course of aging-related events. The transcriptome is extensively remodeled with age, but the temporal trajectories of these changes, particularly through midlife, remain poorly defined in many tissues. Here, we address this gap in the male mo...
Maja Olecka, Konstantin Riege, Madlen Haase et al.· bioRxiv· 0 citations
During aging, the gut microbiome undergoes profound compositional and functional changes that may compromise host health. Using metabolic modeling and mouse studies, we showed that aging is associated with reduced microbial cooperation, lower production of beneficial metabolites, accumulation of pro-inflammatory comp...
Analysis of the interaction between two key gut microbes under deoxycholic acid (DCA) stress suggests that metabolic cooperation enhances resistance to bile acid stress and may contribute to gut microbiome resilience, with potential relevance to liver- and bile acid-related disorders.
Yan Wang, Sven-Bastiaan Haange, Andy Mercado Gamarra et al.· bioRxiv· 0 citations
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