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Christopher J. Fields

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#gene editing Open access Sep 2026

Engineering circular RNA expression systems to minimize contaminating linear RNA byproducts

Circular RNAs (circRNAs) are generated by backsplicing of eukaryotic protein-coding transcripts and can regulate microRNAs and RNA binding proteins, or serve as translation templates. Their covalently closed structure confers resistance to exonuclease-mediated degradation, extending their half-life and supporting their...

Christopher J. Fields, Rina Fujiwara, Bradley W. Wright et al. · 0 citations

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