Author

Christopher M. Rose

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Sep 2026

Molecular mechanism of HUWE1-HAPSTR1-USP7-mediated ubiquitin chain amplification on nuclear proteins.

The HUWE1-HAPSTR1-USP7 complex is established as a key ubiquitin code modifier, providing a molecular rationale for HUWE1 dysregulation in neurodevelopmental disorders and cancer.

S. Yatskevich, Jugal Mohapatra, R. Mroue et al. · Molecules and Cells · 0 citations

Sep 2026

Integrated morphological, multi-omics, and functional profiling reveals microglial plasticity driven by AD risk genes

It is shown that depletion of these AD risk genes disrupts baseline morpho-transcriptomic coupling and fundamentally alters microglial phagocytic capacity, revealing how AD GWAS genes may drive microglia into dysfunctional states characterized by altered morphology, distinct multi-omic signatures, and impaired function...

Ying-Jie Zhang, Ai Zhang, Sang Seo et al. · bioRxiv · 0 citations