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Author

Chunhai Fan

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Review Jul 2026

Innate Immunity of Framework Nucleic Acids.

This Account reviews efforts to develop framework nucleic acids (FNAs) as a platform with modulable innate immunostimulation for biomedical applications in live cells and in vivo, and envision FNAs as intelligent tools for precision immunomodulation, bridging nanoscale design with immunological outcomes to advance pers...

Lin-Jie Guo, Fei Zhou, Ying Zhu et al. · 0 citations
Open access Jul 2026

Direct Cytosolic Delivery of Amphiphilic Framework Nucleic Acids for RNA Interference.

A class of amphiphilic framework nucleic acids (ampFNAs) that enable direct cytosolic delivery involving energy-independent traversal of lipid membranes and establishes ampFNAs as a programmable, efficient, and biocompatible platform for the development of next‑generation smart nucleic acid delivery machines for precis...

Lixuan Lin, Kai Jiao, Biancheng Wei et al. · 0 citations
#protein folding Aug 2026

Direct Visualization of Orientation Competition in Protein Epitaxial Crystallization.

In situ atomic force microscopy is used to reveal the two-dimensional crystallization dynamics of streptavidin on muscovite mica with single-molecule resolution, establishing a paradigm of domain coarsening in biomolecular epitaxy, providing a solid foundation for the rational design of functional bio-nano interfaces.

Yuhui Wei, D. Czajkowsky, Wei Zheng et al. · 0 citations

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