Review
Jul 2026
From synaptic development to degeneration: a narrative review of small molecule strategies targeting alpha-synuclein in Parkinson’s disease
In conclusion, small-molecule-based therapies represent a promising multi-targeted strategy for PD; however, key translational challenges and unresolved questions remain, including optimisation of pharmacokinetics, target specificity, and blood-brain barrier penetration and validation in clinical settings.
L. Khoo, K. Ng, Cien Leong Chye et al.
· Metabolic brain disease · 0 citations