Cleverson de Souza

Journal of Pathology Informatics

Macrophage state and Mycobacterium avium subsp. paratuberculosis persistence in cattle: An evidence-to-claim framework.

Johne's disease is a chronic granulomatous enteritis of ruminants caused by Mycobacterium avium subsp. paratuberculosis (MAP). Macrophages are a major intracellular niche for MAP and a defining cellular component of bovine intestinal lesions, but results obtained from different tissues, donor groups, cell systems, MAP...

Lipopolysaccharide induces a delayed iron-handling transcript pattern in primary bovine macrophages.

Objective To characterize the timing and between-cow consistency of iron-handling transcript changes after lipopolysaccharide (LPS) exposure in primary bovine monocyte-derived macrophages. Methods Macrophages from 5 adult Holstein donor cows were exposed to Escherichia coli LPS or PBS and profiled by RNA sequencing a...